Is Bisglycinate the Same as Glycinate? Understanding the Difference
The terms "bisglycinate" and "glycinate" are often used in the context of mineral supplements, specifically referring to the form in which a mineral is bound to the amino acid glycine. While related, they are not exactly the same, and understanding the distinction is crucial for informed supplement choices.
What is Glycinate?
Glycinate refers to a mineral chelated with one molecule of glycine. Glycine is a non-essential amino acid that plays various roles in the body, including protein synthesis and neurotransmitter production. When a mineral is chelated with glycine, it means the mineral is bound to the glycine molecule, improving its absorption and reducing the potential for gastrointestinal upset. This chelation process makes the mineral more bioavailable, meaning your body can more easily absorb and utilize it.
What is Bisglycinate?
Bisglycinate, on the other hand, indicates that the mineral is chelated with two molecules of glycine. The "bis" prefix signifies "two." This means that each mineral ion is bound to two glycine molecules, potentially leading to even greater stability and bioavailability compared to a simple glycinate form. The increased number of glycine molecules can further enhance absorption and reduce potential side effects, like stomach upset.
Key Differences Summarized:
| Feature | Glycinate | Bisglycinate |
|---|---|---|
| Glycine Molecules | One per mineral ion | Two per mineral ion |
| Absorption | Good | Potentially better |
| Stability | Good | Generally considered better |
| Potential Side Effects | Lower than inorganic forms | Even lower than glycinate forms |
H2: What are the benefits of using bisglycinate over glycinate?
While both forms offer improved absorption compared to inorganic mineral salts, the evidence supporting significantly superior bioavailability of bisglycinate over glycinate is not universally conclusive. Some studies suggest that bisglycinate might offer slightly better absorption and reduced side effects, primarily due to enhanced stability and protection from degradation in the digestive tract. However, more research is needed to definitively establish the extent of this advantage in all cases. The choice between glycinate and bisglycinate often comes down to individual tolerance and preference, as well as the specific mineral in question.
H2: Is bisglycinate better for sensitive stomachs?
Because of its enhanced stability and potentially improved absorption, bisglycinate may be gentler on the stomach than inorganic mineral salts or even standard glycinate forms. However, individual reactions vary. People with highly sensitive stomachs might find bisglycinate more tolerable, but this is not guaranteed. Always start with a low dose and monitor your body's response.
H2: Are there any downsides to using bisglycinate?
There are no significant downsides to bisglycinate compared to glycinate, apart from the potential higher cost. Because the production process generally involves more glycine molecules, the price might be slightly higher than for glycinate supplements.
H2: Which is better, bisglycinate or glycinate?
Ultimately, the "better" choice between bisglycinate and glycinate depends on several factors, including:
- Individual tolerance: Some individuals might find one form more easily tolerated than the other.
- Specific mineral: The effectiveness of chelation can vary depending on the mineral being supplemented.
- Cost: Bisglycinate is typically more expensive than glycinate.
- Available research: While both forms generally show improved bioavailability compared to inorganic forms, more comprehensive research is needed to definitively establish the superiority of bisglycinate over glycinate in all situations.
It's always best to consult with a healthcare professional or registered dietitian to determine the most appropriate form and dosage of mineral supplementation for your individual needs and health condition. They can consider your specific circumstances and help you make an informed decision.
